Concern is growing for Savannah Guthrie and her family after her mother, Nancy Guthrie, disappeared from her Arizona home under circumstances authorities now believe may involve a crime.

Nancy Guthrie, 84, was last seen at her residence in the Catalina Foothills area north of Tucson on Saturday. When she did not attend church Sunday morning, a friend alerted police, triggering an immediate search.

Since then, a large-scale search-and-rescue effort has been underway, involving ground teams, aerial units, and investigators working around the clock to locate her.

At an initial press conference, Pima County Sheriff Chris Nanos said the case was being treated with urgency due to Nancy’s age and health. While criminal activity was not initially confirmed, concerns about the home quickly emerged.

By Monday, authorities said their assessment had changed. Sheriff Nanos told People that investigators now believe Nancy was taken from her home against her will, possibly during the night.

He said evidence suggests she went to bed Saturday night and was gone by Sunday morning, and investigators are confident she did not leave on her own.

Nancy’s limited physical mobility makes wandering unlikely, while her sharp mental state deepens concerns. Investigators believe someone entered the home and removed her without consent.

Authorities are reviewing nearby security footage and have collected biological DNA-type evidence from the home, though details have not been released.

Savannah Guthrie has been absent from Today and issued statements thanking the public for prayers and support. The family continues to ask for privacy as investigators work to determine what happened and locate Nancy safely.